J Appl Sci Res 6:1452–1456Īmbrogi V, Artini D, De CI, Castellino S, Dradi E, Logemann W, Meinardi G, Di SM, Tosolini G, Vecchi E (1970) Studies on the antibacterial and antifungal properties of 1, 4-naphthoquinones. The study of structure–activity relationships is very important in the search for new antimicrobial drugs due to the limited therapeutic arsenal.Īl-Mussawi AA (2010) Isolation and identification of shikonin from Arnebia Decumbens L. These compounds showed higher activity against fungi, but the antibacterial activities were very low. aureus, and 2-chloro-5,8-dihydroxy-1,4-naphthoquinone, with an MIC of 2 µg/mL in C. Halogen derivatives of 1,4-naphthoquinone presented strong activity, e.g., 2-bromo-5-hydroxy-1,4-naphthoquinone, which exhibited inhibition at an MIC of 16 µg/mL in S. The Candida species were the most susceptible microorganisms. A series of 50 naphthoquinone derivatives was synthesized and evaluated for antibacterial and antifungal activity against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Candida krusei, Candida parapsilosis and Cryptococcus neoformans using the broth microdilution method. The synthesis of 1,4-naphthoquinone derivatives is of great interest since these compounds exhibit strong activity as antimalarial, antibacterial, antifungal and anticancer agents.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |